How does it work?

  1. Select a Platform or Data Source
  2. Enter a HGNC-approved Gene Symbol
  3. Choose one of the available plots

mRNA expression. Blue lines represent 25%, 50% and 75% quartiles. Red line represents the current selection.

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Summary statistics

Paired t-test

Tukey's Honest Significant Difference (HSD)

The table shows the difference between pairs, the 95% confidence interval and the p-value of the pairwise comparisons:

Pairwise t tests

Pairwise comparisons between group levels with corrections for multiple testing (p-values with Bonferroni correction):

Kaplan-Meier estimator survival analysis

We apologize, but this feature is still not currently available

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

Abstract
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased intratumoral heterogeneity and presence of tumor microenvironment. In silico cell sorting identified macrophages/microglia, CD4+ T lymphocytes, and neutrophils in the glioma microenvironment. NF1 deficiency resulted in increased tumor-associated macrophages/microglia infiltration. Longitudinal transcriptome analysis showed that expression subtype is retained in 55% of cases. Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence. Hypermutation at diagnosis or at recurrence associated with CD8+ T cell enrichment. Frequency of M2 macrophages detection associated with short-term relapse after radiation therapy.